Discover Scientific Knowledge

Showing results for: "gene mutation" (30 results)

Organoid-Based Toxicity Testing as a Replacement for Animal Models
Health & Medicine

Organoid-Based Toxicity Testing as a Replacement for Animal Models

Animal models have traditionally served as the cornerstone of drug safety evaluation; however, major translational challenges persist due to interspecies differences in physiology, metabolism, and genetic regulation. Many compounds demonstrating favorable toxicity profiles in animals later fail during human trials or are withdrawn post-marketing due to unforeseen adverse effects, especially hepatotoxicity and cardiotoxicity (Lee et al., 2025).

By Jasvitha Mandava

Unlocking the Fortress: How Nano-Messengers are Rewiring the Future of Brain Medicine
Health & Medicine

Unlocking the Fortress: How Nano-Messengers are Rewiring the Future of Brain Medicine

This architecture is essential for shielding neurons from toxins, pathogens, and fluctuations in the bloodstream, but it also creates a devastating bottleneck for modern medicine. More than 98% of small-molecule drugs and nearly all large biological therapeutics fail to cross the BBB in meaningful amounts, leaving many promising treatments for neurodegenerative disorders, brain tumors, and inflammatory diseases stranded in the circulation.

By Nicolás Mario Lisnovsky

Peroxygenases as powerful and sustainable biocatalysts in modern biochemistry
Science & Research

Peroxygenases as powerful and sustainable biocatalysts in modern biochemistry

Selective oxidation reactions are central to modern biochemistry. They enable the controlled introduction of oxygen into organic molecules, a key step in the synthesis of pharmaceuticals and fine chemicals. However, many of the enzymatic systems traditionally used for these transformations are complex and difficult to implement in practice.

By Nicolás Mario Lisnovsky

Cancer, Cooperation, and Survival: Rethinking Disease Through Evolution
Health & Medicine

Cancer, Cooperation, and Survival: Rethinking Disease Through Evolution

In this study, I explore how cancer risk is distributed across the animal kingdom, emphasizing the role of life-history traits, reproductive strategies, and social behavior in shaping susceptibility to disease. Drawing on recent findings in comparative oncology, the article examines patterns that challenge traditional assumptions, such as the relationship between body size and cancer, and highlights evolutionary mechanisms that may confer resistance in certain species.

By Nicolás Mario Lisnovsky

From Cells to Mini-Brains: A New Era for Understanding Parkinson’s Disease
Health & Medicine

From Cells to Mini-Brains: A New Era for Understanding Parkinson’s Disease

Understanding the human brain remains one of the greatest challenges in modern science. With billions of neurons forming intricate networks and constantly changing connections, the brain’s complexity makes it extremely difficult to study directly.

By Nicolás Mario Lisnovsky

What Stress Does to Your Body: The Neurobiology of Stress
Health & Medicine

What Stress Does to Your Body: The Neurobiology of Stress

What does stress actually do to your body? Explore the neurobiology of the survival response, from the immediate SAM axis to the the HPA axis, and learn how to restore your biological equilibrium.

By P. Keerthi Priya

DNA Data Storage: The Future of Biological Archiving
Health & Medicine

DNA Data Storage: The Future of Biological Archiving

As global data generation continues to grow exponentially, traditional storehouse innovations face challenges related to capacity, energy consumption, and long- term preservation. DNA data storehouse offers a revolutionary result by garbling computerized information into synthetic DNA molecules. This explores DNA data storage, its basics, uses, benefits, and ethics, and how it could change future data archiving.

By Bushra Mahmud

← PreviousPage 2 of 2