Health & Biology
Organoid-Based Toxicity Testing as a Replacement for Animal Models
Animal models have traditionally served as the cornerstone of drug safety evaluation; however, major translational challenges persist due to interspecies differences in physiology, metabolism, and genetic regulation. Many compounds demonstrating favorable toxicity profiles in animals later fail during human trials or are withdrawn post-marketing due to unforeseen adverse effects, especially hepatotoxicity and cardiotoxicity (Lee et al., 2025).
