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Showing results for: "mucosal immunity" (24 results)

Organoid-Based Toxicity Testing as a Replacement for Animal Models
Health & Biology

Organoid-Based Toxicity Testing as a Replacement for Animal Models

Animal models have traditionally served as the cornerstone of drug safety evaluation; however, major translational challenges persist due to interspecies differences in physiology, metabolism, and genetic regulation. Many compounds demonstrating favorable toxicity profiles in animals later fail during human trials or are withdrawn post-marketing due to unforeseen adverse effects, especially hepatotoxicity and cardiotoxicity (Lee et al., 2025).

By Jasvitha MandavaNov 9, 2025
Cancer, Cooperation, and Survival: Rethinking Disease Through Evolution
Health & Biology

Cancer, Cooperation, and Survival: Rethinking Disease Through Evolution

In this study, I explore how cancer risk is distributed across the animal kingdom, emphasizing the role of life-history traits, reproductive strategies, and social behavior in shaping susceptibility to disease. Drawing on recent findings in comparative oncology, the article examines patterns that challenge traditional assumptions, such as the relationship between body size and cancer, and highlights evolutionary mechanisms that may confer resistance in certain species.

By Nicolás Mario LisnovskyMar 30, 2026
Unlocking the Fortress: How Nano-Messengers are Rewiring the Future of Brain Medicine
Health & Biology

Unlocking the Fortress: How Nano-Messengers are Rewiring the Future of Brain Medicine

This architecture is essential for shielding neurons from toxins, pathogens, and fluctuations in the bloodstream, but it also creates a devastating bottleneck for modern medicine. More than 98% of small-molecule drugs and nearly all large biological therapeutics fail to cross the BBB in meaningful amounts, leaving many promising treatments for neurodegenerative disorders, brain tumors, and inflammatory diseases stranded in the circulation.

By Nicolás Mario LisnovskyMar 10, 2026
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